Are branded and generic versions of the same medication the same?

particle_page_imgTypical pharmaceutical processes for the manufacture of tablets, capsules, films, and suspensions make extensive use of pharmaceutical particle technology and nanotechnology. The properties of active ingredients and excipients (particle size, shape, electrical behavior, interfacial interactions) determine how powders flow, whether powder blends remain homogeneous or segregate, whether powders mix readily with water and many other phenomena that are essential to formulating and manufacturing pharmaceutical products. These properties, in combination with processing methods, determine the structure, functionality, and quality of pharmaceutical products.

Typical product attributes, including content uniformity, dissolution profile, and tablet hardness, depend both on the properties and proportions of ingredients and on the product microstructure.

Understanding this structure-function-performance relationship is quickly becoming a focal point of pharmaceutical product and process development, and consequently, is rapidly emerging as an essential area of IP litigation. Acumen BioPharma has assembled a powerful team of world-class experts, supported by a comprehensive array of state-of-the-art equipment and methodologies to test material properties and pharmaceutical product microstructure, including:

  • Scanning Electron Microscopy
  • Energy Dispersive Spectroscopy (EDS or EDX)
  • 3D Raman Scanning Microscopy
  • Near-Infrared Chemical Imaging (NIR-CI)
  • X-ray Computer Tomography (X-ray CT)